Digestive and Liver Diseases / Nursing

Overview

The Digestive & Liver Diseases / Nursing research area is composed by three groups, whose main goal is to develop basic and traslational studies on the most frequent and impacting digestive and liver disorders afflicting the general population. In particular, the group of Physiology and Pathophysiology of the Digestive Tract integrates investigations on the function of the gastrointestinal tract including secretion, motility and absorption with cellular, molecular, immune and genetic aspects and their interactions with the microbiota and the brain-gut axis. The Liver Diseases Group deals clinical and basic research in viral hepatitis, liver cirrhosis, liver cancer and also non-alcoholic fatty liver disease and their complications. Finally, our area includes the Multidisciplinar Nursing research group which aims to generate knowledge in the specific area of activity of nurses and collaborate with other health professionals to improve care given to patients.

Publications

129

total

952

impact factor

7.38

average impact factor

Group Leader: Fernando Azpiroz Vidaur

team

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In 2020, the group continued to investigate the role of the microbiota-gut-brain axis in functional and inflammatory disorders of the gastrointestinal tract. Specific research lines investigate the influence of exogenous factors such as stress and diet, or endogen factors such as sex. A key goal is the identification of innovative non-invasive biomarkers for the diagnosis, prevention and management of functional gut disorders. We have continued our internationalization in terms of grants, publications, participation in different consortia, and most importantly our involvement in the design of clinical guidelines for gastrointestinal diseases in Europe. Our research has attracted considerable mediatic interest in television, radio and press. It is worth highlighting the coordination of our group of a project from H2020 ( Project DISCOvERIE; Javier Santos IP) financed by the European Community.

37

total

169

impact factor

4^.57

average impact factor

SELECTED ARTICLES

Le Nevé B, de la Torre AM, Tap J, Derrien M, Cotillard A, Barba E, Mego M, Nieto Ruiz A, Hernandez-Palet L, Dornic Q, Faurie JM, Butler J, Merino X, Lobo B, Batet FP, Accarino A, Pozuelo M, Manichanh C, Azpiroz F.
A Fermented Milk Product with B. Lactis CNCM I-2494 and Lactic Acid Bacteria Improves Gastrointestinal Comfort in Response to a Challenge Diet Rich in Fermentable Residues in Healthy Subjects.
Nutrients 12(2): 320, 2020.
doi: 10.3390/nu12020320.
IF: 5.717
Lleal M, Sarrabayrouse G, Willamil J, Santiago A, Pozuelo M, Manichanh C.
A single faecal microbiota transplantation modulates the microbiome and improves clinical manifestations in a rat model of colitis.
EBioMedicine. 2019 Oct;48:630-641.
doi: 10.1016/j.ebiom.2019.10.002.
IF: 8.143
Guilarte M, Vicario M, Martínez C, de Torres I, Lobo B, Pigrau M, González-Castro A, Rodiño-Janeiro BK, Salvo-Romero E, Fortea M, Pardo-Camacho C, Antolín M, Saperas E, Azpiroz F, Santos J, Alonso-Cotoner C.
Peripheral Corticotropin-Releasing Factor Triggers Jejunal Mast Cell Activation and Abdominal Pain in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.
Am J Gastroenterol. 2020 Dec;115(12):2047-2059.
doi: 10.14309/ajg.0000000000000789.
IF: 10.864
Salvo-Romero E, Martínez C, Lobo B, Rodiño-Janeiro BK, Pigrau M, Sánchez-Chardi AD, González-Castro AM, Fortea M, Pardo-Camacho C, Nieto A, Expósito E, Guagnozzi D, Rodríguez-Urrutia A, de Torres I, Farré R, Azpiroz F, Alonso-Cotoner C, Santos J, Vicario M.
Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome.
Sci Rep. 2020 Nov 26;10(1):20706.
doi: 10.1038/s41598-020-77176-x.
IF: 4.379
Malagelada C, Bendezú RA, Seguí S, Vitrià J, Merino X, Nieto A, Sihuay D, Accarino A, Molero X, Azpiroz F.
Motor dysfunction of the gut in cystic fibrosis.
Neurogastroenterol Motil 2020;32:e13883.
doi: 10.1111/nmo.13883
IF: 3.598

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