Neurovascular Diseases : VHIR Annual Report 2020

Vascular Biology and Metabolism (VAM)

< Back

Overview

The VAM area was created to allow a comprehensive, cooperative and multidisciplinary approach in basic, clinical and epidemiology research. The ultimate goal is the innovation and transfer of solutions in a group of diseases that are closely interrelated and that constitute the leading cause of morbidity and mortality in the world: cardio-cerebrovascular disease, diabetes-metabolic syndrome and renal impairment. The VAM area includes preclinical and clinical research staff from our center, and collaborative work with groups of the highest international prestige. VAM area includes 8 groups: Cardiovascular Pathology, Diabetes and Metabolism, Nephrology, Ophthalmology (focused on retinal vascular disease), CIBBIM-Nanomedicine and Kidney Physiopathology, Medical Molecular Imaging, Neurovascular Diseases, and Research on Aging, Frailty and Transitions in Barcelona. All groups use an integrative tridimensional approach to generate knowledge on the mechanisms of diseases to generate new diagnostic and therapeutic tools.

Publications

281
total
1353
impact factor
4.81
average impact factor

Group Leader: Anna Rosell Novel

This 2020 we have used advanced data integration methods for a multi-level joint analysis of transcriptomics and proteomics data sets obtained from mouse brains after cerebral ischemia identifying a network of molecules that might be considered as blood biomarkers & therapeutic targets of ischemic stroke. We have also started a new nanotechnology project funded through the Albus Award 2020 granted by Grifols with an albumin-based approach for the diagnosis and future treatment of Alzheimer’s disease. The ongoing Magbbris project has successfully developed biocompatible nanocapsules with multimodal imaging properties for encapsulating therapeutic progenitor’s cells secretome. Finally, we studied the role of blood pressure levels and kidney function in the progression of cognitive decline and cerebrovascular lesions in hypertensive patients. In parallel, several long-term international collaborations have resulted in high-impact publications in the neurosciences and cell biology fields.

VHIR Annual Report 2020