Neurosciences

Overview

The Neuroscience area is consolidating its position as one of the largest clusters of research labs working on neurological diseases across Europe. At present, the area comprises 14 groups with more than one hundred fully dedicated researchers in close contact with top clinicians in the hospital. These research groups pursue a better and multifaceted understanding of the etiopathogenic mechanisms underlying a large variety of mostly adult but also pediatric neurological disorders including stroke, multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, primary headaches, epilepsy, neuromuscular disorders, and also neurosurgical and psychiatric pathologies. The area also integrates groups involved in neuroimaging, analysis and interpretation of high-throughput data, and gene therapy strategies to target inflammatory and neurodegenerative neurological conditions.

Publications

316

total

1898

impact factor

6.01

average impact factor

Group Leader: Patricia Pozo Rosich

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Our group has continued to work on our main overarching project the Migraine Adaptive Brain Program. Migraine is complex hereditary brain disorder, which helps us understand how the brain communicates and adapts to change through the sensory processing of internal and external stimuli. Our mission is to study brain function by analyzing how neural networks adapt, respond and communicate with cognitive circuits and the environment through sensory networks, and to transfer this knowledge to diagnose, treat and prevent brain disorders, such as migraine. We also aim to develop evidence-based approaches to enhance individual abilities and non-cognitive skills, and improve brain sense technological devices, with the ultimate goal of promoting self- knowledge and globally increasing the quality of life. Once these functions are better understood we will improve individual abilities and develop therapeutic solutions.

In 2020, we were working with 4 phase III and 2 phase IV clinical trials focused on studying acute and preventive treatments for migraine.

22

total

111

impact factor

5^.05

average impact factor

SELECTED ARTICLES

Mulleners, W. M., Kim, B. K., Láinez, M. J. A., Lanteri-Minet, M., Pozo-Rosich, P., Wang, S., Tockhorn-Heidenreich, A., Aurora, S. K., Nichols, R. M., Yunes-Medina, L., & Detke, H. C.
Safety and efficacy of galcanezumab in patients for whom previous migraine preventive medication from two to four categories had failed (CONQUER): a multicentre, randomised, double-blind, placebo-controlled, phase 3b trial.
The Lancet. Neurology. 19(10):814-825.
DOI: 10.1016/s1474-4422(20)30279-9
IF: 30.039
Alpuente, A., Tassorelli, C., Diener, H. C., Silberstein, S. D., & Pozo-Rosich, P.
Have the IHS Guidelines for controlled trials of acute treatment of migraine attacks been followed? Laying the ground for the 4th edition.
Cephalalgia. 2020 Jul;40(8):778-787.
DOI: 10.1177/0333102420906843
IF: 4.868
Diener, H. C., Tassorelli, C., Dodick, D. W., Silberstein, S. D., Lipton, R. B., Ashina, M., Becker, W. J., Ferrari, M. D., Goadsby, P. J., Pozo-Rosich, P., Wang, S. J., Houle, T. T., Hoek, T. C. V. D., Martinelli, D., & Terwindt, G. M.
Guidelines of the International Headache Society for controlled trials of preventive treatment of migraine attacks in episodic migraine in adults.
Cephalalgia. 2020 Sep;40(10):1026-1044.
DOI: 10.1177/0333102420941839
IF: 4.868
Caronna, E., Ballvé, A., Llauradó, A., Gallardo, V. J., Ariton, D. M., Lallana, S., López Maza, S., Olivé Gadea, M., Quibus, L., Restrepo, J. L., Rodrigo-Gisbert, M., Vilaseca, A., Hernandez Gonzalez, M., Martinez Gallo, M., Alpuente, A., Torres-Ferrus, M., Pujol Borrell, R., Alvarez-Sabin, J., & Pozo-Rosich, P.
Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.
Cephalalgia 2020; 40(13), 1410–1421.
DOI: 10.1177/0333102420965157
IF: 4.868
Torres-Ferrús M, Ursitti F, Alpuente A, Brunello F, Chiappino D, de Vries T, Di Marco S, Ferlisi S, Guerritore L, Gonzalez-Garcia N, Gonzalez-Martinez A, Khutorov D, Kritsilis M, Kyrou A, Makeeva T, Minguez-Olaondo A, Pilati L, Serrien A, Tsurkalenko O, Van den Abbeele D, van Hoogstraten WS, Lampl C; School of Advanced Studies of European Headache Federation (EHF-SAS).
From transformation to chronification of migraine: pathophysiological and clinical aspects.
J Headache Pain. 2020 Apr 29;21(1):42.
DOI: 10.1186/s10194-020-01111-8
IF: 4.797

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